The Second Thing
Tadalafil and/or its metabolites can be found in the milk of lactating rats at concentrations approximately 2.4-fold higher than found in the plasma. In another rat prenatal and postnatal development study at doses of 60, 200, and 1000 mg/kg, a decrease in postnatal survival of pups was observed. The no observed effect level for maternal toxicity was 200 mg/kg/day and for developmental toxicity was 30 mg/kg/day. Thus giving approximately 16 and 10 fold exposure multiples, respectively, of the human AUC for the MRHD of 20 mg. There have been no treatment-related testicular findings in rats or mice treated with doses up to 400 mg/kg/day for 24 months. Physicians should instruct patients on the correct administration of CIALIS to allow optimal use.